Dutch Harbor Omega™ Capsules
- One Serving (2 Softgels) contains a naturally occurring spectrum of omega-3 fatty acids with bioactive pro-resolving mediators, as well as all-natural forms of vitamin A and vitamin D
- Supports healthy immune function*
- Sourced from Alaskan cod that are line-caught in the pristine waters of the Bering Sea; skilled fishermen flash freeze the fish livers immediately to preserve nutrient integrity
- Extracted, minimally processed, and expertly crafted at a state-of-the art fishery that has been certified for sustainability by the Marine Stewardship Council (MSC)
- Non-GMO, gluten-free, no synthetic ingredients added
- Cost is less than $1.00 per day
- Pleasant tasting natural lemon flavor
- Take 2 softgels, 1 to 2 times daily with food or as directed by your healthcare practitioner.
- Form: Softgel
- Serving Size: Two Softgels
- Number of Capsules: 120
- Number of Servings: 60
- Immunity, Immune Response, Immune Rejuvenation
The pristine waters of the Aleutian Islands are home to scores of fish species, including one that has been linked to health and wellness for more than a century: Alaskan Cod. This is a fish that contains high levels of omega-3 fatty acids, including EPA, DHA, and DPA. Studies show that omega-3 fatty acids are linked to immune function and energy metabolism, as well as building healthy nerves, brains, and cell membranes.* Because omega-3s have been shown to improve chemical messaging and cell structure inside the body, these fats may help us respond better to immune challenges, enhance recovery after injury or overexertion, and even manage stress.*
A DEEP DIVE INTO DUTCH HARBOR OMEGA™
REJUVENATE FOR RESILIENCE!
ALASKAN COD LIVERS
Why cod liver—how did this even become a “thing”? To understand the product, you must first understand the fish. Alaskan cod swim in deep, cold water—very extreme conditions. To survive and thrive, these fish need strong immune systems and their livers play an essential role. In cod, the liver accounts for nearly 20% of the weight of the fish. The large size of this organ tells us quite a lot about the metabolic power that is needed to keep a fish resilient in a harsh environment. In Alaskan cod, a unique nutrient composition is paired with exceptionally efficient biochemical machinery. The result: cod livers contain natural substances that have been linked to immune defense and human resilience for more than a century.*
By now, courtesy of reality television, most people have some level of familiarity with the commercial fishing industry. There was a time in the not-so-distant past when irresponsible fishing practices brought our seas to the brink of crisis. Indeed, the threats of depletion and habitat loss have not entirely passed. The time is now for intentional and conscientious stewardship of our oceans and marine life. Big Bold Health partners with fishermen who use hook-and-line equipment and flash freeze the fish immediately after harvesting, which are practices that humane, eco-friendly, and set high standards for quality. Our team enthusiastically supports these important efforts that protect our vital planetary resources.
OMEGA-3 FATTY ACIDS
The nutrients that takes center stage in any conversation about fish oil are the omega-3 fatty acids: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and docasapentaenoic acid (DPA). For adults, EPA, DHA, and DPA are important. We can use other kinds of fats for energy, but for best immune function, energy metabolism, and building healthy nerves, brains, and cell membranes, we need omega-3s.* The unique properties of omega-3 fats help us on all of these levels because they improve chemical messaging and cell structure inside the body.*
PRO-RESOLVING MEDIATORS (PRMs)
Just when you think you know it all, science tells you to think again. Pro-resolving mediators (PRMs) are natural molecules that are produced by EPA and DHA—two of the omega-3 fatty acids—and they have only recently been discovered. Interestingly, PRMs are found in human breast milk, and it is thought that the role they play there is to support the developing immune system of the infant.* They are also found elsewhere in nature, and one of the most significant sources is raw or minimally processed fish oil. Researchers all around the world are now studying PRMs. As biochemical mediators, these molecules appear to regulate inflammatory processes, modulate infection, and influence cellular repair after tissue injury.*
Cod liver oil contains a natural form of vitamin A. Industrial processing methods can often strip this important nutrient from oil that is destined for consumer products, but Big Bold Health’s proprietary system retains the integrity of this ingredient. Vitamin A is well-known to be very important for the support of immune function and it can be significant in activating genes that regulate immune defense.*
Like vitamin A, the all-natural form of vitamin D that is present in the livers of Alaskan cod at the time they are caught and frozen is preserved through the consciously crafted standards that Big Bold Health follows. Vitamin D is a bit of a virtuoso: studies show that it can affect a broad swath of physical, metabolic, cognitive, and mood-related functions.* Within the immune system, vitamin D can play a role in immune balance, cytokine production, infectious disease risk, and regulation of inflammation.*
Here at Big Bold Health, quality is very important to us. Our team is committed to environmental responsibility and regeneration, scientific innovation, and manufacturing methods that embody the spirit of craftsmanship.
*These statements have not been evaluated by the Food and Drug Administration. This product is not
intended to diagnose, treat, cure, or prevent any disease.
Allaire J, Couture P, Leclerc M, et al. Randomized, crossover, head-to-head comparison of EPA and DHA supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA Study. Am J Clin Nutr 2016; doi: 10.3945/ajcn.116.131896.
Arnardottir HH, Dalli J, Colas RA, et al. Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines. J Immunol 2014;193:4235-4244.
Calder PC. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 2006;83(Suppl):1505S-1519S.
Calder PC. Mechanisms of action of (n-3) fatty acids. J Nutr 2012;142:592S-599S.
Chawla A. Control of macrophage activation and function by PPARs. Circ Res 2010;106(10):1559-1569.
Claria J, Dalli J, Yacoubian S, et al. Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat. J Immunol 2012;189(5):2597-2607.
Corder KE, Newsham KR, McDaniel JL, et al. Effects of short-term docosahexaenoic acid supplementation on markers of inflammation after eccentric strength exercise in women. J Sports Sci Med 2016;15:176-183.
Dangi B, Obeng M, Nauroth JM, et al. Biogenic synthesis, purification, and chemical characterization of anti-inflammatory resolvins derived from docosapentaenoic acid (DPAn-6). J Biol Chem 2009;284(22):14744-14759.
Delfan M, Ebrahim K, Baesi F, et al. The immunomodulatory effects of fish-oil supplementation in elite paddlers: a pilot randomized double blind placebo-controlled trial. Prostaglandins Leukot Essent Fatty Acids 2015;99:35-40.
Endo J, Sano M, Isobe Y, et al. 18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling. J Exp Med 2014;211(8):1673-1687.
Espersen GT, Grunnet N, Lervang HH, et al. Decreased interleukin-1 beta levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3 polyunsaturated fatty acids. Clin Rheumatol 1992;11(3):393-395.
Ferguson JF, Mulvey CK, Patel PN, et al. Omega-3 polyunsaturated fatty acid supplementation and the response to evoked endotoxemia in healthy volunteers. Mol Nutr Food Res 2014;58(3):601-613.
Gonzalez-Periz A, Horrillo R, Ferre N, et al. Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: a role for resolvins and protectins. FASEB J 2009;23(6):1946-1957.
González-Périz A, Planagumà A, Gronert K, et al. Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA. FASEB J 2006;20(14):2537-2539.
Han JM, Patterson SJ, Speck M, et al. Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity. J Immunol 2014;192:623-629.
Hirakata T, Lee HC, Ohba M, et al. Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses. FASEB J 2019;33(3):3392-3403.
Hong S, Gronert K, Devchand PR, et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 2003;278(17):14677-14687.
Hughes DA, Pinder AC, Piper Z, et al. Fish oil supplementation inhibits the expression of major histocompatibility complex class II molecules and adhesion molecules on human monocytes. Am J Clin Nutr 1996;63(2):267-272.
Isobe Y, Arita M, Matsueda S. Identification and structure determination of novel anti-inflammatory mediator resolvin E3, 17,18-dihydroxyeicosapentaenoic acid. J Biol Chem 2012;287(13):10525-10534.
Itariu BK, Zeyda M, Hochbrugger EE, et al. Long-chain n-3 PUFAs reduce adipose tissue and systemic inflammation in severely obese nondiabetic patients: a randomized controlled trial. Am J Clin Nutr 2012;96:1137-1149.
James MJ, Gibson RA, Cleland LG. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 2000;71(1 Suppl):343S-348S.
Jaudszus A, Gruen M, Watzl B, et al. Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. J Lipid Res 2013;54:923-935.
Jouris KB, McDaniel JL, Weiss EP. The effect of omega-3 fatty acid supplementation on the inflammatory response to eccentric strength exercise. J Sports Sci Med 2011;10:432-438.
Kiecolt-Glaser JK, Belury MA, Andridge R, et al. Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: a randomized controlled trial. Brain Behav Immun 2012;26(6):988-995.
Kolahi S, Ghorbanihaghjo A, Alizadeh S, et al. Fish oil supplementation decreases serum soluble receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio in female patients with rheumatoid arthritis. Clin Biochem 2010;43(6):576-580.
Kremer JM, Lawrence DA, Jubiz W, et al. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects. Arthritis Rheum 1990;33(6):810-820.
Kromhout D, de Goede J. Update on cardiometabolic health effects of ω-3 fatty acids. Curr Opin Lipidol 2014;25(1):85-90.
Larsson SC, Kumlin M, Ingelman-Sundberg M, et al. Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. Am J Clin Nutr 2004;79(6):935-945.
Lee TH, Hoover RL, Williams JD, et al. Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med 1985;312(19):1217-1224.
Mas E, Croft KD, Zahra P, Barden A, Mori TA. Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation. Clin Chem 2012;58(10):1476-1484.
McDaniel JC, Massey K, Nicolaou A. Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. Wound Repair Regen 2011;19(2):189-200.
McNelis JC, Olefsky JM. Macrophages, immunity, and metabolic disease. Immunity 2014;41:36-48.
Merched AJ, Ko K, Gotlinger KH, et al. Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. FASEB J 2008;22:3595-3606.
Mozaffarian D, Wu JH. (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary? J Nutr 2012;142(3):614S-625S.
Mozaffarian D, Wu JH. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 2011;58(20):2047-2067.
Neuhofer A, Zeyda M, Mascher D, et al. Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. Diabetes 2013;62:1945-1956.
Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, et al. Macrophage-specific PPARγ controls alternative activation and improves insulin resistance. Nature 2007;447(7178):1116-1120.
Oh SF, Vickery TW, Serhan CN. Chiral lipidomics of E-series resolvins: aspirin and the biosynthesis of novel mediators. Biochim Biophys Acta 2011;1811(11):737-747.
Oliver E, McGillicuddy F, Phillips C, et al. The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA. Proc Nutr Soc 2010;69:232-243.
Pischon T, Hankinson SE, Hotamisligil GS, et al. Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation 2003;108(2):155-160.
Rees D, Miles EA, Banerjee T, et al. Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. Am J Clin Nutr 2006;83(2):331-342.
Russell FD, Bürgin-Maunder CS. Distinguishing health benefits of eicosapentaenoic and docosahexaenoic acids. Mar Drugs 2012;10(11):2535-2559.
Satoh-Asahara N, Shimatsu A, Sasaki Y, et al. Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia. Diabetes Care 2012;35:2631-2639.
Schmidt EB, Pedersen JO, Varming K, et al. N-3 fatty acids and leukocyte chemotaxis. Effects in hyperlipidemia and dose-response studies in healthy men. Arterioscler Thromb 1991;11(2):429-435.
Schuchardt JP, Ostermann AI, Stork L, et al. Effect of DHA supplementation on oxylipin levels in plasma and immune cell stimulated blood. Prostaglandins Leukot Essent Fatty Acids 2017;121:76-87.
Spencer M, Finlin BS, Unal R, et al. Omega-3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance. Diabetes 2013;62:1709-1717.
Thesing CS, Bot M, Milaneschi Y, et al. Omega-3 polyunsaturated fatty acid levels and dysregulations in biological stress systems. Psychoneuroendocrinology 2018;97:206-215.
Titos E, Clària J. Omega-3-derived mediators counteract obesity-induced adipose tissue inflammation. Prostaglandins Other Lipid Mediat 2013;107:77-84.
Titos E, Rius B, Gonzalez-Periz A, et al. Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype. J Immunol 2011;187(10):5408-5418.
Vik A, Dalli J, Hansen TV. Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid. Bioorg Med Chem Lett 2017;27(11):2259-2266.
Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112(12):1796-1808.
Weitz D, Weintraub H, Fisher E, et al. Fish oil for the treatment of cardiovascular disease. Cardiol Rev 2010;18(5):258-263.
Yamada H, Oshiro E, Kikuchi S, et al. Hydroxyeicosapentaenoic acids from the Pacific krill show high ligand activities for PPARs. J Lipid Res 2014;55(5): 895–904.
Yang R, Chiang N, Oh SF, et al. Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes. Curr Protoc Immunol 2011;Chapter 14:Unit 14.26.