- A custom blend containing a portfolio of phytonutrients that naturally occur in Himalayan
Tartary Buckwheat, and ancient food crop that has been used medicinally in traditional cultures
- Supports rejuvenation of the immune response*
- Contains an exclusive, immune-activating* ingredient called 2-HOBA (2-hydroxybenzylamine)
- Features myHMB® for muscle support*
- Non-GMO, vegetarian, dairy-free, and gluten-free
- Cost per day is just $1.08
- A daily serving of HTB Rejuvenate™ provides levels of rutin, quercetin, hesperidin, luteolin,
diosmin, and 2-HOBA equivalent to consuming ¼ pound of whole-meal Himalayan Tartary
- Take two capsules daily.
- Form: Capsule
- Serving Size: Two Capsules
- Number of Capsules: 120
- Number of Servings: 60
- Immunity, Immune Response, Immune Rejuvenation
Your immune system is one of nature’s greatest innovations. The human body produces more than a million new immune cells every ten seconds, and every new cell represents a microscopic universe of health potential. But damaged immune cells can also accumulate, especially as we age. Biological debris in the immune system is linked to some of the most common issues people struggle with in our modern, fast-paced world: fatigue and low energy, disrupted sleep, skin trouble, allergies, stress, mood, brain fog, and an overall lack of vitality. Modern technology has revealed that Himalayan Tartary Buckwheat is a plant with unique nutrient characteristics, including phytochemicals (basically the compounds that make a plant!) that have been shown to have health-promoting effects on immunity, metabolism, and rejuvenation of cells.
HTB Rejuvenate is a unique blend that has been formulated to support rejuvenation of the immune response.*
Our ingredients are carefully sourced, and Big Bold Health is active in funding small family farms and regenerative agriculture (it’s our way of saying thank you to Mother Earth).
Himalayan Tartary Buckwheat (Fagopyrum tataricum) Blend
Himalayan Tartary Buckwheat (HTB) is a hardy plant that has been farmed in Asia for generations, but is largely unknown in the rest of the world. Modern analyses have revealed that HTB contains significantly higher levels of phytonutrients compared to common buckwheat (Fagopyrum esculentum)—up to a 100-fold increase of certain immune-strengthening flavonoids.* Easy to farm, hard to find, healthy for humans. At Big Bold Health, we think HTB is the next great superfood story.
What is it? A plant chemical that is extremely rare in foods, but it just so happens that Himalayan Tartary Buckwheat is one of the best sources currently known. 2-HOBA’s full name is 2-hydroxybenzylamine, and its being studied for how well it stops the formation of some types of harmful molecules in the body.
Rutin, Quercetin, Hesperidin, Luteolin, and Diosmin
Nutritionally speaking, this portfolio of flavonoids is an orchestra, a symphony, a masterpiece of nature’s genius. Each is unique, but together the are wonderous, especially when it comes to the ways they can influence immune function.* Himalayan Tartary Buckwheat is an impressive source of all five members of this very special quintet.
In plants, chlorophyll turns light into energy. What can it do for humans? It turns out that it can improve the way the body deals with certain toxins and gets rid of them.* At sufficient levels, chlorophyll can protect DNA and chromosomes—and even help cells repair themselves from damage.*
myHMB® (Calcium-β-hydroxy β-methyl butyrate monohydrate)
This nutrient, which is found in alfalfa and other foods, has been studied for immune support and rejuvenation, as well as the ways it helps build, maintain, and protect muscles and lean tissues throughout the body.*
Here at Big Bold Health, quality is very important to us. We strive to produce products that are ethically and sustainably sourced, evidence-based, and expertly crafted.
*These statements have not been evaluated by the Food and Drug Administration. This product is not
intended to diagnose, treat, cure, or prevent any disease.
Aiello A, Farzaneh F, Candore G, et al. Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention. Front Immunol 2019;10:2247.
Amin MU, Khurram M, Khattak B, et al. Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus. BMC Complement Altern Med 2015;15:59.
Arazi H, Taati B, Suzuki K. A Review of the Effects of Leucine Metabolite (β-Hydroxy-β-methylbutyrate) Supplementation and Resistance Training on Inflammatory Markers: A New Approach to Oxidative Stress and Cardiovascular Risk Factors. Antioxidants (Basel) 2018;7(10). pii:E148.
Askari G, Ghiasvand R, Feizi A, et al. The effect of quercetin supplementation on selected markers of inflammation and oxidative stress. J Res Med Sci 2012;17(7):637-641.
Chen Y, Liu S, Leng SX. Chronic Low-grade Inflammatory Phenotype (CLIP) and Senescent Immune Dysregulation. Clin Ther 2019;41(3):400-409.
Cheng A. Review: Shaping a sustainable food future by rediscovering long-forgotten ancient grains. Plant Sci 2018;269:136-142.
Davies SS, Bodine C, Matafonova E, et al. Treatment with a gamma-ketoaldehyde scavenger prevents working memory deficits in hApoE4 mice. J Alzheimers Dis 2011;27(1):49-59.
Davies SS, Zhang LS. Reactive Carbonyl Species Scavengers—Novel Therapeutic Approaches for Chronic Diseases. Curr Pharmacol Rep 2017;3(2):51-67.
Dong J, Zhang X, Zhang L, et al. Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1. J Lipid Res 2014;55(3):363-374.
Dower JI, Geleijnse JM, Gijsbers L, et al. Supplementation of the Pure Flavonoids Epicatechin and Quercetin Affects Some Biomarkers of Endothelial Dysfunction and Inflammation in (Pre)Hypertensive Adults: A Randomized Double-Blind, Placebo-Controlled, Crossover Trial. J Nutr 2015;145(7):1459-1463.
Dziedzic K, Górecka D, Szwengiel A, et al. The Content of Dietary Fibre and Polyphenols in Morphological Parts of Buckwheat (Fagopyrum tataricum). Plant Foods Hum Nutr 2018;73(1):82-88.
Egert S, Bosy-Westphal A, Seiberl J, et al. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: A double-blinded, placebo-controlled cross-over study. Br J Nutr 2009;102:1065-1074.
Engelen MPKJ, Deutz NEP. Is β-hydroxy β-methylbutyrate an effective anabolic agent to improve outcome in older diseased populations? Curr Opin Clin Nutr Metab Care 2018;21(3):207-213.
Frasca D, Diaz A, Romero M, et al. Ageing and obesity similarly impair antibody responses. Clin Exp Immunol 2017;187(1):64-70.
Fulop T, Larbi A, Dupuis G, et al. Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? Front Immunol 2018;8:1960.
Gill V, Kumar V, Singh K, et al. Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health. Biomolecules 2019;9(12). pii:E888.
Giménez-Bastida JA, Zielinski H, Piskula M, et al. Buckwheat bioactive compounds, their derived phenolic metabolites and their health benefits. Mol Nutr Food Res 2017;61(7). doi:10.1002/mnfr.201600475.
Girón MD, Vílchez JD, Shreeram S, et al. β-Hydroxy-β-methylbutyrate (HMB) normalizes dexamethasone-induced autophagy-lysosomal pathway in skeletal muscle. PLoS One 2015;10(2):e0117520.
González I, Morales MA, Rojas A. Polyphenols and AGEs/RAGE axis. Trends and challenges. Food Res Int 2020;129:108843.
González-Castejón M, Rodriguez-Casado A. Dietary phytochemicals and their potential effects on obesity: A review. Pharm Res 2011;64:438-455.
Jiang P, Burczynski F, Campbell C, et al. Rutin and flavonoid contents in three buckwheat species Fagopyrum esculentum, F. tataricum, and F. homotropicum and their protective effects against lipid peroxidation. Food Res Int 2007;40:356-364.
Jing R, Li HQ, Hu CL, et al. Phytochemical and Pharmacological Profiles of Three Fagopyrum Buckwheats. Int J Mol Sci 2016;17(4). pii:E589.
John K, Divi RL, Keshava C, et al. CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin. Cancer Lett 2010;292(2):254-260.
Katayama S, Ohno F, Yamauchi Y, et al. Enzymatic synthesis of novel phenol acid rutinosides using rutinase and their antiviral activity in vitro. J Agric Food Chem 2013;61(40):9617-9622.
Kim SY, Lee MS, Chang E, et al. Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats. Nutrients 2019;11(3):654.
Koyama M, Obata Y, Sakamura S. Identification of Hydroxybenzylamines in Buckwheat Seeds (Fagopyrum esculentum Moench). Agr Biol Chem 1971;35:1870-1879. Published online: 09 Sep 2014.
Lee MS, Shin Y, Jung S, et al. The Inhibitory Effect of Tartary Buckwheat Extracts on Adipogenesis and Inflammatory Response. Molecules 2017;22(7). pii:E1160.
Lee M, Son M, Ryu E, et al. Quercetin-induced apoptosis prevents EBV infection. Oncotarget 2015;6(14):12603-12624.
Leyva-López N, Gutierrez-Grijalva EP, Ambriz-Perez DL, et al. Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases. Int J Mol Sci 2016;17(6). pii:E921.
Li F, Yuan Y, Yang XI, et al. Phenolic Profiles and Antioxidant Activity of Buckwheat (Fagopyrum esculentum Möench and Fagopyrum tartaricum L. Gaerth) Hulls, Brans and Flours. J Integr Agric 2013;12(9):1684-1693.
Li T, Chen S, Feng T, et al. Rutin protects against aging-related metabolic dysfunction. Food Funct 2016;7(2):1147-1154.
Li W, Qin L, Feng R, et al. Emerging senolytic agents derived from natural products. Mech Ageing Dev 2019;181:1-6.
Lu CL, Zheng Q, Shen Q, et al. Uncovering the relationship and mechanisms of Tartary buckwheat (Fagopyrum tataricum) and Type II diabetes, hypertension, and hyperlipidemia using a network pharmacology approach. PeerJ 2017;5:e4042.
Malavolta M, Pierpaoli E, Giacconi R, et al. Pleiotropic Effects of Tocotrienols and Quercetin on Cellular Senescence: Introducing the Perspective of Senolytic Effects of Phytochemicals. Curr Drug Targets 2016;17(4):447-459.
Mandal SM, Dias RO, Franco OL. Phenolic Compounds in Antimicrobial Therapy. J Med Food 2017;20(10):1031-1038.
Molfino A, Gioia G, Rossi Fanelli F, et al. Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: a systematic review of randomized trials. Amino Acids 2013;45(6):1273-1292.
Nguyen TT, Caito SW, et al. Scavengers of reactive gamma-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7. Aging 2016;8(8):1759–1780.
Pallauf K, Giller K, Huebbe P, et al. Nutrition and healthy ageing: calorie restriction or polyphenol-rich “MediterrAsian” diet? Oxid Med Cell Longev 2013;2013:707421.
Pfeuffer M, Auinger A, Bley U, et al. Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammation in men with different APOE isoforms.
Nutr Metab Cardiovasc Dis 2013;23(5):403-409.
Pitchford LM, Driver PM, Fuller JC Jr, et al. Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial. BMC Pharmacol Toxicol 2020;21(1):3.
Pitchford LM, Rathmacher JA, Fuller JC, et al. First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers. BMC Pharmacol Toxicol 2019;20:1.
Qiu J, Li Z, Qin Y, et al. Protective effect of tartary buckwheat on renal function in type 2 diabetics: a randomized controlled trial. Ther Clin Risk Manag 2016;12:1721-1727.
Rojas Á, Del Campo JA, Clement S, et al. Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host Targets. Sci Rep 2016;6:31777.
Rossi AP, D’Introno A, Rubele S, et al. The Potential of β-Hydroxy-β-Methylbutyrate as a New Strategy for the Management of Sarcopenia and Sarcopenic Obesity. Drugs Aging 2017;34(11):833-840.
Sadati SM, Gheibi N, Ranjbar S, et al. Docking study of flavonoid derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. Biomed Rep 2019;10(1):33-38.
Shamalnasab M, Gravel SP, St-Pierre J, et al. A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response. Aging Cell 2018;17(6):e12830.
Siddavaram N, Palitti F, Natarajan AT. Chemopreventive Potential of Chlorophyllin: A Review of the Mechanisms of Action and Molecular Targets. Nutr Cancer 2015;67(2):203-211.
Stevens Y, Rymenant EV, Grootaert C, et al. The Intestinal Fate of Citrus Flavanones and Their Effects on Gastrointestinal Health. Nutrients 2019;11(7). pii:E1464.
Thakur R, Verma ML. Food bioactives with special reference to Himalayan tartary buckwheat. Saarbrucken, Germany; LAP Lambert Academic Publishing: 2017.
Trim W, Turner JE, Thompson D. Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity. Front Immunol 2018;9:169.
Wieslander G, Fabjan N, Vogrincic M, et al. Eating buckwheat cookies is associated with the reduction in serum levels of myeloperoxidase and cholesterol: a double blind crossover study in day-care centre staffs. Tohoku J Exp Med 2011;225(2):123-130.
Wu W, Li R, Li X, et al. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses 2015;8(1). pii:E6.
Wu J, Saleh MA, Kirabo A, et al. Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest 2016;126(1):50-67.
Xia S, Zhang X, Zheng S, et al. An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment. J Immunol Res 2016;2016:8426874.
Zhang L, Li X, Ma B, et al. The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance. Mol Plant 2017;10(9):1224-1237.
Zhu F. Chemical composition and health effects of Tartary buckwheat. Food Chem 2016;203:231-245.