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Science eons in the making.

Immuno-Rejuvenation: Nature’s Wisdom Abounds

Big Bold Health is pioneering a new approach to whole-body wellbeing. Immuno-Rejuvenation (IR) harnesses the power of nature and the body’s innate defenses to build resilience into the immune response.

By rejuvenating cells and rebalancing immune function, IR helps the body’s vital systems work in concert — clearing the path to robust physical and mental health as we age.

The passionate pursuit of life-changing health

Dr. Jeffrey Bland is widely regarded as the father of functional medicine. He’s spent 40 years developing breakthrough approaches in the fields of holistic health and nutrition.

Seeing the profound difference his work made in people’s lives, Dr. Bland founded Big Bold Health to multiply the impact. Today he's unlocking the promise of Immuno-Rejuvenation for everyone.

“I’ve met many people who’ve told me, sometimes in tears, ‘Do you realize you saved my life?’ We feel a deep responsibility to bring this knowledge to as many people as possible.”

Dr. Jeffrey Bland

Here’s the Proof

Dozens of independent clinical studies conclude that immune performance is critical
to systems throughout the body and a primary factor in maximizing healthspan.
BBH Initiated

We measured the impact of HTB Rejuvenate on more than 850,000 epigenetic markers to understand the connections between aging, immunity, and the key compounds of HTB.

Study concluded. Publication and writeup forthcoming.
Read the Study Design

Vital Elements of IR

  • Polyphenols
    Immune-active plant nutrients. Himalayan Tartary Buckwheat is uniquely rich in key polyphenols like quercetin and rutin.
  • Pro-resolving mediators (PRMs)
    Naturally present in white blood cells, PRMs work in combination with nutrients in fish oil to balance and resolve your immune response.
  • Microbiome
    The majority of your immune cells live in your gut microbiome. Pre- and probiotics play a key role in harmonizing this community of microorganisms.
  • Autophagy
    The body's cellular recycling program. This is the rejuvenation side of your immune system, vital for maximizing healthspan.
  • Senescence
    The process of aging and decline. Immuno-senescence is something we all face, but there's an antidote — Immuno-Rejuvenation.


Rejuvenate your immune system
to feel younger and stronger.

Active Ingredients

Polyphenols from Himalayan Tartary Buckwheat. Found in some of Earth’s harshest climates, this ancient plant is cultivated for its astonishing wealth of immune-active nutrients including 2-HOBA, quercetin, and rutin.

  • Strengthen immune performance*
  • Promote cellular health*
  • Increase energy*
  • Increase focus & clarity*
  • Gut health & support*
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Resolve the imbalances in your immune system
to feel calmer and sharper.

Active Ingredients

Omega-3s and pro-resolving mediators. Our sustainably sourced omega-3s come from fish line-caught in the cold, clear waters of Alaska. They’re processed at low temperatures to retain vitamins A and D and high levels of EPA, DHA, DPA, ESA, and PRMs.

  • Balances immune response*
  • Support for cognition*
  • Improve mood*
  • Support for cardiovascular & heart health*
  • Support for skin & eye health*
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Restore your immunity through the gut
to feel energized and vital.

Active Ingredients

Prebiotics, probiotics, polyphenols. We combine nutrients from the seeds of the Himalayan Tartary Buckwheat plant with probiotics and beta glucans from microalgae to balance immunity through the gut.

  • Balances immune response*
  • Supports gut immunity*
  • Support for gut & microbiome health*
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